Healing is a complex and intricate process initiated in response to an injury that restores the function and integrity of damaged tissues. Herbal medicines in wound management involve disinfection, debridement and providing a moist environment to encourage the establishment of the suitable environment for natural healing process. The aqueous extract of the aerial parts of Leucas aspera was prepared as per protocol. The rats were divided into three groups comprising of 6 rats each. Group I served as wound control and an excision wound was created using a sharp surgical blade and pointed scissors for an area of 200mm2 and a depth of 0.2 cm. Group II was wounded and treated with aqueous extract of Leucas aspera. Group III was wounded and treated with a standard drug Soframycin. The following parameters were studied in the granulation tissue and serum – Collagen, Hexoseamine, ascorbic acid, LPO and SOD. The wounded animals showed significant decrease in the collagen, hexoseamine, SOD and ascorbic acid levels with a marked increase in the LPO levels. On treatment of the wounds with AELA there was tissue regeneration which was evident from the increased levels of tissue collagen, hexoseamine, ascorbic acid and SOD. The increased activity of SOD resulted in the scavenging of the free radicals and hence there was a significant reduction in the LPO levels. The data obtained was statistically analysed and p<0.05 was considered to be statistically significant. From the results obtained it was evident that Leucas aspera possessed wound healing activity.
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